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Diabetes Metab Res Rev (2000) 16(4):2306

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Perhaps most importantly, this patent also broadly defined inteins as CIVPSs and identified them based on specific conserved features (Figure 2), thereby providing prior art that would apply to new intein sequences that had not yet been discovered and many of their applications ( FIGURE 2 The methods described by this patent had revolutionary implications in protein engineering

Birkhauser Verlag, Basel Klaassen CD, Liu J, Chaudhari S (1999) Metallothionein: an intracellular protein to protect against cadmium toxicity