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Yu X, Li Y, Zhang Y, Yin K, Chen X, Zhu X

More direct evidence for the translocation of zinc was provided by the findings of Koh and others (11), who demonstrated that during a brief period of global ischemia, intracellular zinc accumulation in vulnerable CA1 pyramidal hippocampal neurons preceded degeneration, which could be prevented with the intracerebroventricular administration of the high affinity, membrane-impermeable zinc-chelator, ethylenediaminetetraacetic acid (EDTA) saturated with calcium (Ca-EDTA)

doi: 10.1136/jitc-2020-001372 17 ZouZChangHLiHWangS

Tomita K, Smith PM, Takayama M, Pan C, Shen S, Wang X, Wang XS, Williams LA, Arvide EM, To C, Rajaram R, Mitchell KG, Rice DC, Hofstetter W, Antonoff MB , Mehran RJ, Vaporciyan A, Walsh GL, Maxwell JE, Snyder RA, Kim MP, Tzeng CW, Mansfield PF, Swisher SS, Lee J, Badgwell BD, Katz M, Ikoma N