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O'Brien S, Kantarjian H, Keating M, Beran M, Koller C, Robertson LE, Hester J, Rios MB, Andreeff M , Talpaz M

It is also required for synthesis of nucleic acid, notably DNA, the metabolism of fatty acids and amino acids in the mitochondria, and in delivering SAMe, the universal methyl donor (16) (30)

It is the standard diluent used across virtually all peptide research protocols for reconstituting lyophilized peptides

This role is particularly crucial in red blood cells because, being oxygen carriers par excellence, they have a literally built-in danger of damage by oxygen radicals generated continuously in the course of methemoglobin formation