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Significant accumulation of fibrillar A has been observed in the PCC relative to other brain regions in early-onset AD patients using positron emission tomography (PET) 48

Retrieved 17 April 2017

Since degenerative processes within the peripheral nervous system are only a part of CIPN, we also need to understand the role of central nervous system changes (neuroplasticity and the central sensitization of neuropathic pain), neuromodulators, neurotransmitters and receptors implicated in the phenomena that induce CIPN [185]