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A complete overlap of the individual estimated disposition PK parameter value (CL, V c, Q , V p ) distributions, and the expected distributions (based on demographic characteristics) of the parameter values obtained from the s.c./i.v

NCT04982575

New England Journal of Medicine (2023) 2

3.2 Role of TGF- in radiation skin fibrosis TGF- is a cytokine intricately involved in the fibrotic process across various organs and tissues ( 3.2.1 TGF- Signaling and cellular mechanisms in radiation-induced fibrosis TGF- exerts its effects through the activation and proliferation of fibroblasts, leading to ECM accumulation ( TGF- expression is dose-dependent on radiation exposure, binding to its receptors to form a trimeric complex which can lead to tissue fibrosis ( Figure 2 )