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Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

MCF7 cells were used in the majority of experiments because they are known to have very little endogenous GSTP1 due to GSTP1 silencing by hypermethylation of the CpG dinucleotides at the 5 transcriptional regulatory region [46]

Moreover, the reduced form of GSH directly detoxifies ROS and controls the activities pertaining to GSH dependent ROS and MG detoxifying enzymes 9,53

3 Results 3.1 Bodyweight evaluation Mean body weight did not show statistically significant differences among groups and during the periods evaluated in this study ( p = 0.42), as shown in Figure 2