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Effect of cold atmospheric plasma on epigenetic changes, DNA damage, and possibilities for its use in synergistic cancer therapy

Clioquinol: it is an oral anti-parasitic agent and recently displays preclinical efficacy in malignancy through inhibiting proteasome and directing Cu to proteasome and in Alzheimer through recovering intracellular Cu content (Schimmer, 2011

While the precise molecular mechanism of TRIM16 action on the p62-Nrf2 system has not been completely defined, TRIM16 expression is associated with increased p62 phosphorylation (Pertel et al., 2011) and other TRIMs (Versteeg Gijs et al., 2013), that phosphorylates p62 (Kehl et al., 2019) and is required for p62 body formation in response to multiple cellular stresses (Kehl et al., 2019)