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In: Adam MP, Everman DB, Mirzaa GM, et al, eds

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Stable isotope-assisted metabolomics for deciphering xenobiotic metabolism in mammalian cell culture

A study employing high-resolution immunocytochemistry at both light and electron microscopic levels in rodents has demonstrated that neurons efficiently uptake lactate via monocarboxylate transporter 2 (MCT2), a high-affinity transporter localized at postsynaptic densities to facilitate lactate import from astrocyte-released sources (Bergersen, 2007) and subsequently convert it to pyruvate via lactate dehydrogenase isotype 1