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[DOI] [PMC free article] [PubMed] 114.Henry JA, Jeffreys KJ, Dawling S

Gluten exposure rapidly increases intestinal permeability within hours to a few days, primarily through gliadin, which activates toll-like receptor 2 and 4 (TLR2 and TLR4) in macrophages, leading to NF-B overexpression and the release of pro-inflammatory cytokines such as TNF- ( , IFN- , and IL-15 exacerbate this dysfunction, creating a vicious cycle of barrier disruption and inflammation ( The gut microbiota represents another critical component of the pathophysiological cascade in CD

57 The clinical trial proved that Molnupiravir had the potential to lower the risk of hospitalization and mortality

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