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induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells

(Stockler-Pinto et al ., 2009) Unlike primary antioxidants that can cope with high volumes of free radicals, the secondary (non-enzymatic) antioxidants, such as vitamins, minerals and polyphenols, which are sourced via the diet, have a more limited capacity to quench free radicals

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POPs are mainly excreted through conjugation with GSH and this mechanism is extremely important for the health status, since exposure to POPs has been associated to diabetes, cardiovascular diseases and many other chronic diseases ( ROS production can occur at several intracellular sites but, for most cells, takes place in the mitochondria and the mitochondrial electron transport chain is the main cellular process of ROS generation in physiological circumstances ( 2 O 2 )