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The mice were housed in cages placed in a quiet and temperature-humidity controlled room (22C1-2C) with a 12 hr light-dark cycle

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At steady state, active BACE1 is predominantly found in the endosomes, where a lower pH (around pH 4.5) is optimal for -secretase activity (Vassar et al, 1999), although some studies have also reported BACE1 activity at the TGN (Thinakaran et al, 1996

How long alcohol stays in your system depends on several factors, including how much you drink, how quickly you drink it, and how your body processes alcohol