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Reactive oxygen species and the mitochondrial signaling pathway of cell death

, 45 , 1461-1480, doi: Teskey, G., Abrahem, R., Cao, R., Gyurjian, K., Islamoglu, H., Lucero, M., Martinez, A., Paredes, E., Salaiz, O., Robinson, B., and Venketaraman, V

Finally, the slices were rinsed with PBS, and images of the sample sections were acquired using a Leica DMI-3000B microscope (Leica, Germany)

Epigenetic heterogeneity within tumors and treatment-driven clonal evolution Epigenetic heterogeneity within tumors is a major driver of treatment failure [196], with plasticity far exceeding that of genomic mutations, making it a key force in adaptive evolution [6]