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IgA autoantibodies in wAIHA did not seem to have the same effect described for the autoantibodies in cAIHA and did not induce RBC eryptosis unless the RBCs were opsonized [330]

doi: 10.1079/BJN19840122

The difference comes down to one critical factor most hangover guides ignore: first-pass metabolism destroys nearly all oral glutathione before it reaches circulation, while IV delivery bypasses the gut entirely