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This deacetylation process effectively restores the positive charge of lysine residues, leading to chromatin condensation and gene repression

Indirect methods are used to obtain lead compounds by analyzing the three-dimensional structure and conformation of the active small molecule to create a pharmacophore model and subsequently searching a small molecule library for compounds that match the pharmacophore model

DBAN also advanced DNA replication in the other two mutant strains but later and to a lesser extent (Fig

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