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Additionally, chronic estradiol application promotes the expression of interleukin (IL)1, IL-6, IL-12p40, and Inducible nitric oxide synthase (iNOS) in macrophages following lipopolysaccharide (LPS) stimulation, further enhancing immune responses [105]

10.1016/S0027-5107(01)00142-7 45 KatanoK.KondoA.SafaeiR.HolzerA.SamimiG.MishimaM.et al

Figure 1 3.2 Cancer prevention There is a sizable and biologically plausible body of research connecting plant-based dietary patterns to lower cancer risk, though in a more subtle and cancer-site specific manner than the cardiometabolic evidence ( Large cohort studies that have been conducted, including the Adventist Health Study-2 and the EPIC-Oxford study, have indicated that the incidence of certain types of cancer, including colorectal and gastrointestinal cancers, is low in individuals who follow plant-predominant diets

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