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This might be due to the enhancement of T cell infiltration and increased lymphatic drainage, APC trafficking, and antigen transportation to TDLNs

consequently, reduced or temporally/spatially mismatched Treg-derived cytokines (TGF-, IL-10, and IL-35) can weaken mucosal tolerance and reparative programs, whereas context-dependent Treg overexpansion may impair antimicrobial immunity, resulting in dysregulated intestinal homeostasis 50,51

This indicates that the introduction of GHK promotes wound healing, and the addition of cell surface-reactive cell-targeting peptide (RGD) enhances the wound-healing process of GHK

[12] Jrgensen JO, Mller J, Laursen T, Orskov H, Christiansen JS, Weeke J