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Histone acetyltransferase 1 promotes cell proliferation and induces cisplatin resistance in hepatocellular carcinoma

Abstract This study aims to elucidate the synergistic protective mechanism of the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in ischemia-reperfusion injury -associated acute kidney injury (IRI-AKI)

Despite this robust preclinical evidence, studies on human hypertension remain at an early exploratory stage, highlighting the need for large-scale randomized controlled trials to establish clinical efficacy

They should explain the off-label nature of cosmetic glutathione use and provide realistic expectations about results and maintenance requirements