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Supportive therapies are now only enabling to prevent a deterioration of cases once at the hospital or ahead of time to avoid intubation

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In addition to DNAm, cigarette smoking is linked to the activation of enzymes that regulate other types of epigenetic modifications (i.e., post-translational modifications of histones via methylation, acetylation, phosphorylation, ubiquitination, and regulation of non-coding RNA sequences) to mediate the expression of multiple inflammatory genes, thereby participating in the onset development of autoinflammatory diseases (135)