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These irregular patterns were unlikely to be associated with dilution of intracellular contents by the pipette solution, as identical results could be detected using loose patch-clamp to rule out cell dialysis artefacts 19 (Fig

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To address these gaps, future research should prioritize larger scale multicenter randomized controlled trials with standardized protocols, adequately powered biomarker-guided RCTs with harmonised clinical endpoints plus GSH/GSSG, MDA/TBARS, SOD/CAT/GPx panels, head-to-head monotherapy vs

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