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Within sensible limits, the basics help your body hold its levels: a diet that includes B12 sources if you are not vegan, limiting heavy alcohol use, and not smoking, since both affect how you absorb and store nutrients

Do not use as a substitute for evaluation of persistent pain, swelling, gastrointestinal bleeding, or suspected tendon rupture

Health status considerations: Generally healthy adults with physician clearance, individuals without contraindications (pregnancy, active malignancy, severe organ disease), those willing to commit to proper administration protocols and monitoring, and patients who understand the research-purposes-only status and informed consent requirements

These numbers were unprecedented when first published and set the benchmark that all subsequent obesity treatments have been measured against