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These molecules target enzymes that break down proteins, which is particularly relevant in conditions where excessive protein degradation contributes to disease pathology

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However, the terminal amino and sulfhydryl groups are mostly in their protonated forms at pH 7 resulting in two labile protons for reduced glutathione (GSH), see Equation 23 on Scheme 2a

Within the literature, a singular case is reported of an obese patient with obstructive sleep apnea (OSA) who experienced excessive daytime sleepiness (EDS) despite receiving optimal treatment and having a severe deficiency in vitamin B12