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These findings suggest that the combination of small molecule NNMT inhibitors with other nutritional supplements, such as the precursors of NAD + , may have the potential to enhance the efficacy of treatment for MetS and minimize the side effects caused by high pharmacological dosages (Roberti et al., 2021)

From our perspective IGF-1, GH, and insulin conform a finely regulated axis that inform cells about the nutritional status of the organism so that they can either undergo apoptosis/senescence/quiescence or, to the contrary, grow and differentiate

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