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M.BreuningM

doi: 10.1080/19490976.2021.1894070 10 QiXYunCSunLXiaJWuQWangYet al

These environments include ischemia-hypoxia-reperfusion during placental development, pathological changes in physiological uterine contractions or superficial placental perfusion, trophoblastic iron enrichment, evidence of lipotoxicity during the pathophysiology of major placenta-related diseases such as PE, fetal growth restriction, and preterm birth, and decreased GSH redox capacity and lipid peroxidation repair capacity during placental injury [29]

The activation of the AMPK signaling pathway could induce ferroptosis by down-regulating SLC7A11 expression through inhibition of mTOR/p70S6k signaling pathway in colorectal cancer [112]