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doi: 10.1038/s41591-019-0674-1 [DOI] [PMC free article] [PubMed] [Google Scholar] 68.Baughn MA-O, Melamed ZA-O, Lpez-Erauskin J, et al

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In the coronavirus-related model, hesperetin effectively reduced the mRNA and protein expression of IL-6, IL-1 and IL-18 by blocking the interaction network between Akt/MAPK/AP-1 and NLRP3 in A549 and THP-1 cells, with a minimum active concentration of 5 g/mL and an action time of 27 h, suggesting that it has dual effects of cytoprotection and inflammation antagonism ( 7 Synthesis and future perspectives TCM natural products in treating viral pneumonia lie in their multi-target, multi-pathway synergistic regulation of the inflammation-oxidative stress network, establishing a dynamic balance of anti-inflammatory, antioxidant, and antiviral effects (Zhang et al., 2025)

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