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The AOD 9604 with tirzepatide combination guide covers this topic in detail, but the core logic is worth examining here

doi: 10.1002/ueg2.12060 163 SenT.CawthonC

Both act through the ghrelin/GHSR pathway, but Ipamorelin is generally discussed as more selective, while GHRP-6 is an older GH-releasing peptide often associated with appetite-related signaling