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Trends Plant Sci 22(1):1119 Mostofa MG, Seraj ZI, Fujita M (2014) Exogenous sodium nitroprusside and glutathione alleviate copper toxicity by reducing copper uptake and oxidative damage in rice ( Oryza sativa L.) seedlings

Because administration of high doses of reduced folic acid (folinic acid) or even folic acid itself can reverse the antiproliferative effects of methotrexate, it is clear that methotrexate does act as an antifolate agent

The figure is conceptual in nature and was developed by the authors based on previously published literature on circadian aging