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Notably, DNA damage is one of the most potent triggers of p53 activation

We also noted that we anticipate initiating analysis of the impact of improper payments on an ACO's payment determination upon learning of improper payments originating inside the ACO that may potentially impact Shared Savings Program calculations, and may reopen the ACO's payment determination, as needed, to address program integrity concerns

10.3389/fphar.2023.1264842 27 BrockmannK.ApelA.SchulteC.Schneiderhan-MarraN.Pont-SunyerC.VilasD.et al (2016)

We will also continue to explore requiring that covered entities and their contracted 340B third-party administrators (340B TPAs) report retrospectively at a minimum the 4 elements we described and solicited comment on in the CY 2025 PFS proposed rule (89 FR 61971)