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Later complications can include liver fibrosis, cardiomyopathy, diabetes, and arthropathy

Discussion We provide, for the first time, direct evidence that only 38 days of extra oral glucose intakes four times a day can induce prediabetes

On the one hand, TME immunomodulation can trigger macrophage polarization from alternately activated macrophages M2 to classically activated macrophages M1, offering intertumoral H 2 O 2 for the Fenton reaction (Zanganeh et al., 2016), which effectively generates ROS and triggers lipid peroxidation (Yang and Stockwell, 2016

Her thyroid was actually able to produce more of its own thyroid hormone