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10.3390/nu12051330 54 PathakP.HelsleyR

GABA is an essential endogenous inhibitory neurotransmitter in the mammalian brain and plays a fundamental role in maintaining the excitatory-inhibitory balance of neural networks (79)

Pharmaceutical agents such as Cox-2 inhibitors, thalidomide, megestrol, medroxyprogesterone acetate, melatonin, and DCA, and supplemental nutrients or antioxidants from food [35], such as -3 poly-unsaturated fatty acids, vitamin C, vitamin D, vitamin E, -hydroxy--methylbutyrate (HMB) [36] and lycopene, represent potential anti-cachexia treatments that are being explored in clinical trials