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Conclusion Multidrug resistance to chemotherapy drugs is one of the main obstacles in human cancer chemotherapy and has prompted intense research into discovering novel and innovative mechanisms that can overcome this barrier

Simultaneously, improved protein synthesis and cellular hydration make existing muscle appear fuller

In vitro, KYNA protects cortical neurons from reactive glia- and QA-induced atrophy, enhancing neurite complexity and synapse formation, indicating that increasing KYNA or inhibiting glial KP activity can mitigate excitotoxic and inflammatory neuronal damage [86]

Except for the EMs group ( n = 10), the three other groups were intraperitoneally injected with iron dextran (250 g/g, Shanghai Yuanye Bio-Technology Co., Ltd, China, #9004-66-4) every 2 days for 3 consecutive weeks