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Improvement with progesterone withdrawal or suppression: Resolution or marked improvement of symptoms after: Stopping progesterone containing medications Suppressing ovulation (and therefore progesterone production) This response strongly supports progesterone hypersensitivity

Furthermore, our NMR experiments on S 21mer constructs identified S tail residues well upstream the crystallographic footprint that demonstrate CSPs upon binding to WD40 (Supplementary Fig

This finding indicates that rapamycin has an anti-epileptostatic effect as it interferes with epileptogenesis but not epilepsy (Ryther and Wong 2012)