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Introduction In the spectrum of fibrotic conditions, penile fibrosis is characterized by disproportionate accumulation of collagen components in the tunica albuginea, penile corpora cavernosa, and corpus spongiosum, termed as Peyronies disease (PD), corporal fibrosis, and urethral stricture respectively (Milenkovic et al., 2019a)

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Conversely, SirT1-mediated deacetylation activates PGC-1 ( Hyperlipidemia substantially contributes to type 2 diabetes susceptibility

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