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5.1 Overview of ferroptosis Ferroptosis is an iron-dependent form of cell death driven by the accumulation of lipid peroxides ( Ferroptosis depends on iron-dependent lipid peroxidation, with its key signaling regulation falling into three broad categories: iron metabolism, glutathione metabolism, and lipid metabolism ( is an essential amino acid antiporter composed of two subunits, SLC7A11 and SLC3A2

Moreover, they play significant roles in shaping adaptive immunity and function as coordinators of the overall immune and inflammatory responses

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Moreover, tubular injuries were assessed by quantification of HE-stained sections and revealed significantly increased tubulointerstitial injury scores in mice injected with FA injection, which were reduced by LA supplementation in a dose-dependent manner, but without statistical significance