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Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2)

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Importantly, these toxicities are largely due to on-target effects of systemic mitochondrial uncoupling, which result in uncontrolled heat dissipation, decreased ATP production, and increased cytosolic calcium concentration, potentially eventually leading to death