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When in the reduced state, GSH is active and protects cells and DNA by neutralizing reactive oxygen species, such as naturally occurring peroxides and free radicals produced during metabolism that could otherwise damage cellular components

maxima at a concentration of 1000 g/mL showed low toxicity in the human skin fibroblast cell line (CCD-986sk), with cell viability remaining greater than 50% after 24 h of treatment

TPH, tryptophan hydroxylase

Moreover, the interpretation of biomarker responses is complicated by the poor bioavailability and limited bloodbrain barrier penetration of many phytochemicals