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For example, a DNA repair protein, redox factor Ref-1, was reported to promote the DNA-binding activities of several transcription factors, including HIF-1 and p53, which confers cytoprotective function under hypoxia

ICP should be monitored, maintaining it between 20 and 25 mmHg, with a brain perfusion pressure above 50 mmHg.99 When ICP is above 25 mmHg, boluses of hypertonic saline solution or intravenous mannitol at 20% should be added to the treatment.100 29 The presence of HE in a patient with ACLF confers a poor prognosis, increasing the risk for mortality in both the short and long terms

Unlike SIRT5, low expression of SIRT3 leads to increased acetylation and phosphorylation of PDHE1, reduced PDHase activity, and enhanced glycolysis [53]