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doi:10.1016/j.amjoto.2019.03.017

Folate and B12 deficiencies cause the body to produce less glutathione and elevate unmetabolized homocysteine (6)

B12 shots have also been used to enhance athletic performance and treat heart disease, osteoporosis, and anemia

In summary, natural health products in Canada can be assumed to be safe when used according to label instructions, but the issuing of an NPN does not mean that the specific product has been shown to maintain, restore or improve health. It should be realized that an NPN can be obtained without any requirement of evidence from human clinical trials