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Experimental evidence indicates that prolonged oral exposure to PS-MPs (1 m and 5 m) in mice significantly downregulates the expression of tight junction proteinssuch as zonula occludens-1 (ZO-1) and occludinleading to enhanced intestinal permeability

10.1371/journal.pone.0072046 PLoS ONE 35 GaoH.-M.LiuB.HongJ.-S