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Abbreviations BMP: bone morphogenetic protein CMap: Connectivity Map COPD: chronic obstructive pulmonary disease CT: computed tomography DLCO: diffusing capacity of carbon monoxide DMEM: Dulbecco's modified Eagle's medium ECM: extracellular matrix FBS: fetal bovine serum FDR: false discovery rate FEV 1 : forced expiratory volume in 1 second FVC: forced vital capacity GOLD: Global Initiative for Chronic Obstructive Lung Disease GSEA: Gene Set Enrichment Analysis Lm: mean linear intercept PBS: phosphate-buffered saline TGF: transforming growth factor Vv: volume fraction

Future developments in personalized medicine, digital therapeutics, and public health approaches promise to improve outcomes for patients struggling with motivation-related difficulties

These include metabolic syndrome, coronary heart disease, type 2 diabetes mellitus, rheumatoid arthritis, anemia, osteoporosis, and psychological problems

Vitamin B12 combines with and globulin in the blood to be transported to various tissues throughout the body, most of which are distributed in the liver