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Pathophysiology of HT-1 In 1977, fumarylacetoacetate hydrolase (FAH) was identified as the deficient enzyme responsible for HT-1 (Figure 1)

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Some studies propose that macrophage factor IL-1 and Th17 cytokine IL-17A may negatively impact GR function by upregulating the expression of GR subtypes, with GR being the primary structure exerting effects (335, 336)