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The rationale is straightforward: oxidative stress is a recurring theme in egg-quality research, and these ingredients are included to support antioxidant capacity.57 For alpha-lipoic acid and grape seed extract, fertility-specific human data are earlier-stage and largely supportive or mechanistic rather than definitive.58 59 In human studies where these ingredients are evaluated for metabolic or antioxidant effects, the doses used are typically higher often around 300600mg per day for alpha-lipoic acid and 100200mg per day for grape seed extract which suggests their role here is complementary rather than central.60 61 The vitamin E dose (67mg) is a common supplemental amount, well above the adult recommended daily allowance (RDA) of 15mg and still far below the established upper limit of 1,000mg per day.62 One practical consideration is dose flexibility

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Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine -synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy

doi: 10.1155/2020/6012102 61 dos ReisSTPontesJVillanovaFEBorra PM deAAntunesAADalloglioMFet al