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They may: Promote lipolysis (fat breakdown) Increase metabolic efficiency Improve mitochondrial function 4

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[310] A large prospective study reported a 20.3% prevalence of vitamin B12 deciency after 9.5 years of metformin use, [10] and a large dataset provided by the National Health and Nutrition Examination Survey showed a 22% prevalence when vitamin B12 deciency was dened as levels below 300 pg/mL