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Inhibition of key KRAS upstream and downstream molecules can also effectively inhibit KRAS-mediated signal transduction, such as inhibiting upstream signalling, SHP2, and inhibiting downstream signalling, the RAF-MEK-ERK pathway and the PI3K-AKT-mTOR pathway

To further demonstrate the scalability of CHAMP, we screened a library comprising 1152 azide-bearing compounds that was recently described by the Dong and Sharpless groups in their strategy to install azide tags onto molecules using a diazotizing reagent 32