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Extensive research, particularly in lipopolysaccharide (LPS)-stimulated sepsis models, has highlighted that targeting inflammatory signaling and oxidative stress is critical for mitigating lung injury (Zhang et al

Instead, there are some international reports of serious side effects

The compound was also investigated as PL14736 in early-phase IBD clinical work, as described in a 2008 paper by Klicek and colleagues in Journal of Pharmacological Sciences , though that clinical program was never completed or approved