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Table 2 summarizes the key metabolic alterations observed in neurons, astrocytes, and microglia across major neurodegenerative diseases

Gazdhar, A., Lebrecht, D., Roth, M., Tamm, M., Venhoff, N., Foocharoen, C., Geiser, T., & Walker, U

developed supramolecular prodrug nanoassemblies (SPNA) for reactive nitrogen species (RNS)-enhanced chemotherapy (Figure 3D) (Figures 3E, F), thereby generating highly toxic peroxynitrite anion (ONOO )

First, in non-malignant tissues, PDK isoforms play essential physiological roles, particularly in highly energy-demanding organs such as the heart and skeletal muscle, where they regulate substrate utilization by limiting carbohydrate oxidation and promoting metabolic flexibility [190, 191]