perianal melanotic macule

perianal melanotic macule macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Anorectal Melanoma: A Rare Cause

Name: perianal melanotic macule macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Anorectal Melanoma: A Rare Cause
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Anorectal Melanoma: A Rare Cause of Large Bowel Obstruction Cureus Melanotic macule MEDizzy Anorectal melanoma histopathological and immunohistochemical features and treatment ScienceDirect Genital Melanotic Macules DoveMed

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Liu, B., Chen, Y

The expression of core circadian regulators Bmal1 and Clock is downregulated in aging thyroid follicular epithelial cells, suggesting a decline in circadian regulatory capacity, contributing to age-related circadian disruptions (60)