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Trx is able to form hydrogen sulfide and polysulfides in vitro (Figure 3) [101]

Once mixed with a diluent (like bacteriostatic water), the clock starts ticking

10.1021/acs.inorgchem.1c03030 10

Given the importance of glial pathology in the pathogenesis of bipolar disorder and the key role played by GDNF in stabilizing microglia activation and the propagation of peripheral inflammatory signaling in the CNS, we hope that future, methodologically rigorous studies may elucidate its disease state-dependent changes