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Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production

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you can use a moisturising cream after applying the Kojic Acid cream in order to potentially prevent this effect and, if it becomes too dry, you may want to consider using the Kojic Acid cream less frequently