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JY and XF researched the manuscript and identified eligible studies

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In liver cancer, the N-terminal domain of SLC7A11 is specifically recognized by the SOCS2-SH2 domain

On the other hand, error-prone statistical models [276], limited range of genetic and/or environmental variation [277], and study-design inconsistencies, such as inadequately powered studies, measurement errors, or flaws in sample selection might fail in revealing genetic and environmental interactions leading to unreliable conclusions [278, 279]