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Acknowledgements: All authors declare that they have no conflicts of interest

Notably, this study was performed in an in vivo model of HCC and demonstrated a significant tumor reduction within the treated mice by downregulating the interleukin 17 (IL-17) expression and further weakening the angiogenesis ( Figure 4 ) (230)

Reduced Pain and Inflammation

In addition, the role of glucose metabolism impairment was observed in a meta-analysis encompassing more than 1,700,000 patients, finding diabetic patients to have a 38% higher risk of development of PD (Yue et al., 2016), while in another meta-analysis on 86,000 PD patients, prediabetic patients were found to have a 4% higher risk of development of PD compared to individuals with no fasting glucose impairment ( 2.4 Mitochondrial dysfunction Mitochondria are crucial for insulin secretion from pancreatic cells, and their dysfunction contributes to impaired insulin secretion in T2DM